Tissue Chips: Past and Present
Dr. Kristin Bircsak, MIMETAS
The Challenges and Future of Microphysiological Systems
Dr. Seila Selimovic, National Institute of Biomedical Imaging and Bioengineering
January 24, 2019 3:30 – 6:00 pm Doors Open @ 3:30 pm
Evangelical Reformed United Church of Christ (ERUCC), Community Room
15 W. Church Street
Frederick, MD 21701
Talks will begin at 4:00 pm followed by a Q&A panel. Parking is available in either the Court Street or Church Street Garage.
These seminars will focus on recent advances in the Tissue Chip field, an overview of regulatory challenges, as well as future scientific applications. Microphysiological systems (MPS), or Tissue Chips, are 3-D scaffolds composed of human tissues and cells designed to model the structure and function of human organs, such as the lung, liver, and heart. Tissues chip systems can closely mimic human function, in many ways more accurately then 2-D systems and animal models. Scientists have begun to apply these tools to gain insight into disease pathophysiology and accelerate the development of potential therapeutics.
Dr. Kristin Bircsak
Kristin Bircsak is a Senior Scientist with MIMETAS, The Organ-on-a-Chip Company in Gaithersburg, Maryland. In 2016, she received her Ph.D. in Toxicology from Rutgers University following which she completed a postdoctoral fellowship at the University of Pennsylvania. In her training, Kristin utilized various model system to characterize the negative impact of drugs and environmental chemicals on reproduction and development. In her role at MIMETAS, Kristin drives the development of innovative 3D in vitro organotypic models and assays. Her research is centered on recapitulating the liver and prostate microenvironment to aid in the accurate prediction of safe and effective candidate compounds. Importantly, her research efforts contribute to the 3Rs effort of reducing, refining, replacing animal use.
Dr. Seila Selimovic
Dr. Seila Selimovic is Director of three extramural research programs at the National Institute of Biomedical Imaging and Bioengineering: Technologies for Tissue Chips, Engineered Tissues, and Biosensors and Physiological Detectors. In 2015, she was selected as one of the “50 Leaders of Tomorrow” from among hundreds of young biotech leaders in the Mid-Atlantic region. Prior to her current position, she was chosen by the American Association for the Advancement of Science (AAAS) to serve as a Science and Technology Policy Fellow at the U.S. Department of State. Before that, she was a Postdoctoral Research Fellow at Harvard Medical School and Brigham & Women’s Hospital in Boston, Massachusetts, working on heart and liver microphysiological systems. Dr. Selimović’s research has focused on the development of microfluidic platforms for applications in biophysics and biological engineering, including the physics of microscale flows, protein crystallization, colloidal suspensions, as well as rheology and microrheology. Dr. Selimović earned her Ph.D. and M. Sc. degrees in Physics from Brandeis University, and her B.A. degree from Wellesley College.